Type 1 diabetes

STZ model: This type 1 diabetes model is induced by intraperitoneal injection of streptozotocin (STZ), which induces the necrosis of insulin producing β-cells of pancreatic islets.

 

Obesity and type 2 diabetes

Diet-induced model: This model is induced by a chronic 60% fat diet and it is considered both a model of obesity and type 2 diabetes with elevated blood glucose and impaired glucose tolerance.