Animal models

Animal models of neurological and psychiatric disorders

Neuropharmatest’s Disease Models Program is designed to offer you many of the most commonly used and referenced efficacy models of neurological and psychiatric disorders. We offer several of the most popular rodent models, in which we have wide experience. The currently available models are listed below, but if you are interested in a particular model that it is not listed, please contact us.

Additionally, Neuropharmatest researchers are constantly working on the development of new models that will be able to reproduce  more accurately different aspects of these disorders (see research).


Depression | Chronic stress

Chronic restraint stress

Chronic immobilization and acoustic stress

Chronic social stress (Aggression/Sensory-contact model)

Chronic unpredictable mild stress

Olfactory bulbectomy

Maternal separation


Anxiety | Acute stress

Acute restraint stress

Acute immobilization and acoustic stress

Acute social stress

Predator sound/odor stress



MK-801 perinatal injection

Post-weaning social isolation rearing

“Double hit” schizophrenia model: This model combined neurological alterations during perinatal development (MK-801 injection at PND7) and modified environmental conditions (post-weaning social isolation rearing).

Parkinson's Disease

Parkinson’s Disease

6-OHDA model

MPTP model

Rotenone model



Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the use of models of status epilepticus (SE). At Neuropharmatest we are currently offering the following models.

Pilocarpine model

Kainic acid model